Semantically Founded Implementation of Clinical Practice Guidelines

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For many serious diseases, clinical practice guidelines (CPGs) providing detailed advice on diagnostics and treatment are today being made available by medical societies. Although it has been shown that the success rates of treatments can profit more from adherence to the relevant CPG than by any foreseeable innovations in medication or treatment technique, the level of adherence in clinical practice remains regrettably low, causing measurable damage to the quality of treatments and ultimately lowering survival rates. One cause identified for this situation is the volume and logical complexity of CPGs, which constitute an obstacle for their adoption in practice. This creates a need for machine-supported implementations of CPGs which relieve the medical practitioner from the more cumbersome parts of the decision process. The goal of the SIMPLE project, in which DFKI collaborates with ID Berlin, is to develop a logic-based framework for the implementation of guidelines. In this setup, clinical workflows are inferred from a formal knowledge base representing the guideline by means of ontological reasoning, in particular query answering. Envisaged benefits of this approach are increased robustness, reliability, and flexibility of guideline-based clinical workflow management.


ID Information und Dokumentation im Gesundheitswesen GmbH & Co. KGaA, Alfried Krupp Krankenhaus, Essen und die Städtischen Kliniken Neuss


Federal Ministry of Education and Research (BMBF)


Federal Ministry of Education and Research (BMBF)

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Publications about the project

Dieter Hutter, Serge Autexier

In: Juan Carlos Augusto , Reiner Wichert (editor). Proceedings of the Fourth International Joint Conference on Ambient Intelligence. International Joint Conference on Ambient Intelligence (Aml-2013) December 3-5 Dublin Ireland Springer-Verlag, CCIS 12/2013.

To the publication
Serge Autexier, Dieter Hutter,

In: Proceedings of the 10th International Conference & Expo on Emerging Technologies for a Smarter World. International Conference & Expo on Emerging Technologies for a Smarter World (CEWIT-2013) 10th October 21-22 Melville NY United States IEEE Xplore Online 10/2013.

To the publication
Serge Autexier, Dieter Hutter

In: Proceedings of the 26th International Workshop on Description Logics, 2013. International Workshop on Description Logics (DL-13) July 23-26 Ulm Germany Pages 501-512 CEUR 1014 CEUR Workshop Proceedings 7/2013.

To the publication

German Research Center for Artificial Intelligence
Deutsches Forschungszentrum für Künstliche Intelligenz