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Digital Phenotyping for Differential Diagnosis of Major Depressive Episode: Narrative Review

Eric Ettore; Philipp Müller; Jonas Hinze; Michel Benoit; Bruno Giordana; Danilo Postin; Rene Hurlemann; Amandine Lecomte; Michel Musiol; Hali Lindsay; Philippe Robert; Alexandra König
In: JMIR Mental Health, Vol. 10, Page e37225, JMIR Publications Toronto, Canada, 2023.


Major depressive episode (MDE) is a common clinical syndrome. It can be found in different pathologies such as major depressive disorder (MDD), bipolar disorder (BD), posttraumatic stress disorder (PTSD), or even occur in the context of psychological trauma. However, only 1 syndrome is described in international classifications (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [DSM-5]/International Classification of Diseases 11th Revision [ICD-11]), which do not take into account the underlying pathology at the origin of the MDE. Clinical interviews are currently the best source of information to obtain the etiological diagnosis of MDE. Nevertheless, it does not allow an early diagnosis and there are no objective measures of extracted clinical information. To remedy this, the use of digital tools and their correlation with clinical symptomatology could be useful.