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Use and accuracy of decision support systems using artificial intelligence for tumor diseases: a systematic review and meta-analysis

Robert Oehring; Nikitha Ramasetti; Sharlyn Ng; Roland Roller; Philippe Thomas; Axel Winter; Max Maurer; Simon Moosburner; Nathanael Raschzok; Can Kamali; Johann Pratschke; Christian Benzing; Felix Krenzien
In: Frontiers in Oncology, Vol. 13, Pages 1-14, Frontiers Media SA, 2023.


Background For therapy planning in cancer patients multidisciplinary team meetings (MDM) are mandatory. Due to the high number of cases being discussed and significant workload of clinicians, Clinical Decision Support System (CDSS) may improve the clinical workflow. Methods This review and meta-analysis aims to provide an overview of the systems utilized and evaluate the correlation between a CDSS and MDM. Results A total of 31 studies were identified for final analysis. Analysis of different cancers shows a concordance rate (CR) of 72.7% for stage I-II and 73.4% for III-IV. For breast carcinoma, CR for stage I-II was 72.8% and for III-IV 84.1%, P≤ 0.00001. CR for colorectal carcinoma is 63% for stage I-II and 67% for III-IV, for gastric carcinoma 55% and 45%, and for lung carcinoma 85% and 83% respectively, all P>0.05. Analysis of SCLC and NSCLC yields a CR of 94,3% and 82,7%, P=0.004 and for adenocarcinoma and squamous cell carcinoma in lung cancer a CR of 90% and 86%, P=0.02. Conclusion CDSS has already been implemented in clinical practice, and while the findings suggest that its use is feasible for some cancers, further research is needed to fully evaluate its effectiveness.